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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1308314
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nlrp3
Name: NLR family, pyrin domain containing 3
Acc ID: CHEBI:17243
Term: mono(2-ethylhexyl) phthalate
Definition: The mono(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:C016599
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nlrp3increases expressionISONLRP3 (Homo sapiens)6480464CTDmono-(2-ethylhexyl)phthalate results in increased expression of NLRP3 mRNA; mono-(2-ethylhexyl)phthalate results in increased expression of NLRP3 proteinPMID:33159713
Nlrp3increases expressionISONlrp3 (Mus musculus)6480464CTDmono-(2-ethylhexyl)phthalate results in increased expression of NLRP3 proteinPMID:31016965 PMID:37286014 PMID:37692514
Nlrp3multiple interactionsISONlrp3 (Mus musculus)6480464CTD4-phenylbutyric acid inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of NLRP3 protein]; Acetylcysteine inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of NLRP3 protein]; epigallocatechin gallate inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of NLRP3 protein]; Toyocamycin inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of NLRP3 protein]PMID:37286014 PMID:37692514
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