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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10551
Species: Mus musculus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1 (alpha)
Acc ID: CHEBI:17243
Term: mono(2-ethylhexyl) phthalate
Definition: The mono(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:C016599
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1multiple interactionsEXP 6480464CTD[monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in decreased expression of ESR1 mRNA; mono-(2-ethylhexyl)phthalate binds to and results in increased activity of ESR1 proteinPMID:20209442 PMID:31884101
Esr1affects expressionISOESR1 (Homo sapiens)6480464CTDmono-(2-ethylhexyl)phthalate affects the expression of ESR1 mRNAPMID:33631300
Esr1increases expressionISOESR1 (Homo sapiens)6480464CTDmono-(2-ethylhexyl)phthalate results in increased expression of ESR1 mRNA; mono-(2-ethylhexyl)phthalate results in increased expression of ESR1 proteinPMID:33631300 PMID:38042133
Esr1multiple interactionsISOESR1 (Homo sapiens)6480464CTD[monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with monobutyl phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] affects the expression of ESR1 mRNA; ESR1 protein affects the reaction [mono-(2-ethylhexyl)phthalate affects the expression of ESR1 mRNA]; ESR1 protein affects the reaction [mono-(2-ethylhexyl)phthalate affects the expression of MMP2 mRNA]; ESR1 protein affects the reaction [mono-(2-ethylhexyl)phthalate affects the expression of MMP9 mRNA]; ESR1 protein affects the reaction [mono-(2-ethylhexyl)phthalate affects the expression of TIMP2 mRNA]; ESR1 protein affects the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of PCNA mRNA]; mono-(2-ethylhexyl)phthalate binds to and results in increased activity of ESR1 proteinPMID:33049310 PMID:33631300 PMID:35861251
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