GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Hif1a | increases expression | EXP | | 6480464 | CTD | Glucose results in increased expression of HIF1A protein | PMID:21617913 | Hif1a | multiple interactions | EXP | | 6480464 | CTD | 2-Methoxyestradiol inhibits the reaction [Glucose results in increased expression of HIF1A protein]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Glucose results in increased expression of HIF1A protein]; [3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole results in decreased activity of HIF1A protein] results in decreased susceptibility to [Oxygen deficiency co-treated with Glucose deficiency]; [Glucose co-treated with Oxygen deficiency] inhibits the reaction [ARNT protein binds to HIF1A protein]; [Glucose co-treated with Oxygen deficiency] promotes the reaction [Pyruvaldehyde binds to and results in decreased activity of HIF1A protein]; [Glucose co-treated with SOD2 gene mutant form] results in decreased expression of HIF1A protein; [Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of HIF1A protein; [Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of HIF1A mRNA; [Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of HIF1A protein; HIF1A protein affects the reaction [[Glucose deficiency co-treated with Oxygen deficiency] results in decreased expression of BCL2 protein]; HIF1A protein affects the reaction [[Glucose deficiency co-treated with Oxygen deficiency] results in increased cleavage of CASP3 protein]; HIF1A protein affects the reaction [[Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of BAX protein]; HIF1A protein affects the reaction [MIR186 mRNA affects the reaction [[Glucose deficiency co-treated with Oxygen deficiency] results in decreased expression of BCL2 protein]]; HIF1A protein affects the reaction [MIR186 mRNA affects the reaction [[Glucose deficiency co-treated with Oxygen deficiency] results in increased cleavage of CASP3 protein]]; HIF1A protein affects the reaction [MIR186 mRNA affects the reaction [[Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of BAX protein]]; MIR186 mRNA inhibits the reaction [[Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of HIF1A protein] | PMID:18227068 PMID:19228841 PMID:19429140 PMID:21617913 PMID:23108914 PMID:33759271 | Hif1a | decreases expression | ISO | HIF1A (Homo sapiens) | 6480464 | CTD | Glucose results in decreased expression of HIF1A mRNA | PMID:31655124 | Hif1a | increases expression | ISO | Hif1a (Rattus norvegicus) | 6480464 | CTD | Glucose results in increased expression of HIF1A mRNA; Glucose results in increased expression of HIF1A protein | PMID:26891083 | Hif1a | increases expression | ISO | HIF1A (Homo sapiens) | 6480464 | CTD | Glucose results in increased expression of HIF1A mRNA | PMID:33962019 | Hif1a | multiple interactions | ISO | Hif1a (Rattus norvegicus) | 6480464 | CTD | [[Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of HIF1A protein] which results in increased expression of SLC8A1 mRNA; [Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of HIF1A protein; [Oxygen deficiency co-treated with Glucose deficiency co-treated with Oxygen] results in increased expression of HIF1A mRNA; [Oxygen deficiency co-treated with Glucose deficiency co-treated with Oxygen] results in increased expression of HIF1A protein; HIF1A protein affects the reaction [Glucose results in increased expression of CCN2 protein]; HIF1A protein affects the reaction [Glucose results in increased expression of EDN1 protein]; HIF1A protein affects the reaction [Glucose results in increased expression of FN1 protein]; HIF1A protein affects the reaction [Glucose results in increased expression of TGFB1 protein]; HIF1A protein affects the reaction [Glucose results in increased expression of VEGFA protein]; MIR217 mRNA affects the reaction [Glucose results in increased expression of HIF1A mRNA]; MIR217 mRNA affects the reaction [Glucose results in increased expression of HIF1A protein]; Resveratrol inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency co-treated with Oxygen] results in increased expression of HIF1A mRNA]; Resveratrol inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency co-treated with Oxygen] results in increased expression of HIF1A protein]; Resveratrol inhibits the reaction [Glucose results in increased expression of HIF1A mRNA]; Resveratrol inhibits the reaction [Glucose results in increased expression of HIF1A protein]; SIRT1 protein affects the reaction [Resveratrol inhibits the reaction [Glucose results in increased expression of HIF1A protein]] | PMID:21293012 PMID:23421680 PMID:26891083 | Hif1a | multiple interactions | ISO | HIF1A (Homo sapiens) | 6480464 | CTD | [cobaltous chloride co-treated with Glucose] promotes the reaction [HIF1A protein binds to EP300 protein]; [cobaltous chloride co-treated with Glucose] results in increased expression of and results in decreased ubiquitination of HIF1A protein; [Glucose co-treated with Deferoxamine] results in increased expression of HIF1A mRNA; [Oxygen co-treated with Glucose] inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of HIF1A protein]; [Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of HIF1A protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of HIF1A protein]]; Cycloheximide inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of HIF1A protein]; epoxomicin inhibits the reaction [scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of HIF1A protein]]; Glucose affects the reaction [Fusaric Acid affects the expression of HIF1A protein]; Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of HIF1A mRNA]; MG 262 inhibits the reaction [scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of HIF1A protein]]; Particulate Matter inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of HIF1A protein]; scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose co-treated with Cycloheximide] results in decreased expression of HIF1A protein]; scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] promotes the reaction [HIF1A protein binds to EP300 protein]]; scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of and results in decreased ubiquitination of HIF1A protein]; scutellarin promotes the reaction [Cycloheximide inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of HIF1A protein]]; Vehicle Emissions inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of HIF1A protein] | PMID:25192544 PMID:28400208 PMID:31654802 PMID:33962019 | | ||||||||||||||||||||||
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