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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621392
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccn2
Name: cellular communication network factor 2
Acc ID: CHEBI:17234
Term: glucose
Definition: An aldohexose used as a source of energy and metabolic intermediate.
Chemical ID: MESH:D005947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDGlucose results in increased expression of CCN2 mRNA, Glucose results in increased expression of CCN2 protein

PMID:14586741, PMID:26891083
multiple interactionsEXP 6480464CTDAspirin inhibits the reaction [Glucose results in increased expression of CCN2 mRNA], CCN2 protein results in decreased susceptibility to [Oxygen deficiency co-treated with Glucose deficiency], HIF1A protein affects the reaction [Glucose results in increased expression of CCN2 protein], MIR217 mRNA affects the reaction [Glucose results in increased expression of CCN2 protein], Resveratrol inhibits the reaction [Glucose results in increased expression of CCN2 protein], SIRT1 protein affects the reaction [Resveratrol inhibits the reaction [Glucose results in increased expression of CCN2 protein]]

PMID:14586741, PMID:21124846, PMID:26891083
increases expressionISORGD:7310136480464CTDGlucose results in increased expression of CCN2 mRNA, Glucose results in increased expression of CCN2 protein

PMID:10026205, PMID:19369054, PMID:21367880
multiple interactionsISORGD:7310136480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Glucose results in increased expression of CCN2 protein], bisindolylmaleimide I inhibits the reaction [Glucose results in increased expression of CCN2 mRNA], Cadmium inhibits the reaction [Glucose results in increased expression of CCN2 protein], CCL2 mRNA affects the reaction [Glucose results in increased expression of CCN2 protein], SB 203580 inhibits the reaction [Glucose results in increased expression of CCN2 protein], Zinc inhibits the reaction [Glucose results in increased expression of CCN2 protein]

PMID:10026205, PMID:19369054, PMID:21367880
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.