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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620175
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fgf21
Name: fibroblast growth factor 21
Acc ID: CHEBI:17234
Term: glucose
Definition: An aldohexose used as a source of energy and metabolic intermediate.
Chemical ID: MESH:D005947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fgf21affects uptakeISOFGF21 (Homo sapiens)6480464CTDFGF21 protein affects the uptake of GlucosePMID:15902306
Fgf21affects uptakeISOFgf21 (Mus musculus)6480464CTDFGF21 protein affects the uptake of GlucosePMID:15902306
Fgf21increases expressionISOFGF21 (Homo sapiens)6480464CTDGlucose results in increased expression of FGF21 mRNAPMID:27226639
Fgf21increases expressionISOFgf21 (Mus musculus)6480464CTDGlucose deficiency results in increased expression of FGF21 mRNAPMID:27226639
Fgf21increases secretionISOFgf21 (Mus musculus)6480464CTDGlucose results in increased secretion of FGF21 proteinPMID:28123933
Fgf21multiple interactionsISOFGF21 (Homo sapiens)6480464CTDindolo(3,2-b)carbazole inhibits the reaction [Glucose results in increased expression of FGF21 mRNA]; Tetrachlorodibenzodioxin inhibits the reaction [Glucose results in increased expression of FGF21 mRNA]PMID:27226639
Fgf21multiple interactionsISOFgf21 (Mus musculus)6480464CTDindolo(3,2-b)carbazole inhibits the reaction [Glucose deficiency results in increased expression of FGF21 mRNA]; Tetrachlorodibenzodioxin inhibits the reaction [Glucose deficiency results in increased expression of FGF21 mRNA]PMID:27226639
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