GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Bax | affects expression | EXP | | 6480464 | CTD | Glucose affects the expression of BAX protein | PMID:22524206 | Bax | increases expression | EXP | | 6480464 | CTD | Glucose results in increased expression of BAX mRNA; Glucose results in increased expression of BAX protein | PMID:23192364 PMID:26054749 PMID:27234048 PMID:28106847 PMID:28713934 PMID:30144576 PMID:31323227 PMID:36462176 | Bax | multiple interactions | EXP | | 6480464 | CTD | 3,3',4,5'-tetrahydroxystilbene inhibits the reaction [Glucose results in increased expression of BAX protein]; [Dithionite co-treated with Glucose deficiency] results in increased expression of BAX protein; [morroniside co-treated with Diosgenin] inhibits the reaction [Glucose results in increased expression of BAX protein]; [Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in increased expression of BAX protein; [Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of BAX protein; Chloroquine inhibits the reaction [Resveratrol inhibits the reaction [Glucose results in increased expression of BAX protein]]; cinnamic acid inhibits the reaction [Glucose results in increased expression of BAX protein]; Diosgenin inhibits the reaction [Glucose results in increased expression of BAX protein]; dorsomorphin inhibits the reaction [Resveratrol inhibits the reaction [Glucose results in increased expression of BAX protein]]; Metformin inhibits the reaction [Glucose results in increased expression of BAX protein]; morroniside inhibits the reaction [Glucose results in increased expression of BAX protein]; naringenin inhibits the reaction [Glucose results in increased expression of BAX mRNA]; naringenin inhibits the reaction [Glucose results in increased expression of BAX protein]; notoginsenoside R1 inhibits the reaction [[Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in increased expression of BAX protein]; Quercetin affects the reaction [Glucose affects the expression of BAX protein]; Quercetin inhibits the reaction [[Dithionite co-treated with Glucose deficiency] results in increased expression of BAX protein]; Resveratrol inhibits the reaction [Glucose results in increased expression of BAX protein]; sesamin affects the reaction [Glucose affects the expression of BAX protein]; STIM1 protein affects the reaction [Glucose results in increased expression of BAX protein]; trigonelline inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of BAX protein] | PMID:21803128 PMID:22524206 PMID:23192364 PMID:23451161 PMID:25305180 PMID:26054749 PMID:27234048 PMID:28106847 PMID:28713934 PMID:30144576 PMID:31323227 PMID:31935362 | Bax | increases expression | ISO | Bax (Mus musculus) | 6480464 | CTD | Glucose results in increased expression of BAX protein | PMID:29266779 PMID:31672611 | Bax | increases expression | ISO | BAX (Homo sapiens) | 6480464 | CTD | Glucose results in increased expression of BAX mRNA; Glucose results in increased expression of BAX protein | PMID:24218232 PMID:30431688 PMID:30802477 PMID:31115753 PMID:32602595 PMID:37417536 | Bax | multiple interactions | ISO | Bax (Mus musculus) | 6480464 | CTD | 8-dibenzothiophen-4-yl-2-morpholin-4-yl-chromen-4-one promotes the reaction [[Glucose co-treated with Bupivacaine] results in increased expression of BAX protein]; [Glucose co-treated with Bupivacaine] results in increased expression of BAX protein; [Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of BAX protein; [Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of BAX; [Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of BAX protein; [Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of BAX protein modified form; CEBPB protein inhibits the reaction [Glucose results in increased expression of BAX protein]; HIF1A protein affects the reaction [[Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of BAX protein]; HIF1A protein affects the reaction [MIR186 mRNA affects the reaction [[Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of BAX protein]]; MIR186 mRNA affects the reaction [[Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of BAX protein]; MIR186 mRNA inhibits the reaction [[Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of BAX protein]; Resveratrol inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of BAX protein]; SIRT7 protein inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of BAX protein]; U 0126 inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of BAX protein]; Valsartan inhibits the reaction [Glucose results in increased expression of BAX protein] | PMID:24682241 PMID:25238743 PMID:28675767 PMID:29266779 PMID:31672611 PMID:33759271 | Bax | multiple interactions | ISO | BAX (Homo sapiens) | 6480464 | CTD | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [spiraeoside inhibits the reaction [Glucose results in increased expression of BAX protein]]; [Carnosine co-treated with asiatic acid] inhibits the reaction [Glucose results in increased expression of BAX mRNA]; [Glucose co-treated with Deferoxamine] results in increased expression of BAX mRNA; [Glucose co-treated with Deferoxamine] results in increased expression of BAX protein; asiatic acid inhibits the reaction [Glucose results in increased expression of BAX mRNA]; Carnosine inhibits the reaction [Glucose results in increased expression of BAX mRNA]; diallyl trisulfide inhibits the reaction [Glucose results in increased expression of BAX protein]; Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of BAX mRNA]; Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of BAX protein]; MitoTEMPO inhibits the reaction [Glucose results in increased expression of BAX protein]; NDRG2 protein promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of BAX protein]; polyethylene glycol loxenatide inhibits the reaction [Glucose results in increased expression of BAX protein]; Resveratrol inhibits the reaction [Glucose results in increased expression of BAX protein]; salvianolic acid inhibits the reaction [Glucose results in increased expression of BAX protein]; spiraeoside inhibits the reaction [Glucose results in increased expression of BAX protein] | PMID:23451161 PMID:24218232 PMID:30431688 PMID:30802477 PMID:31115753 PMID:32602595 PMID:33962019 PMID:37417536 | | ||||||||||||||||||||||
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