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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2153
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Arnt
Name: aryl hydrocarbon receptor nuclear translocator
Acc ID: CHEBI:17234
Term: glucose
Definition: An aldohexose used as a source of energy and metabolic intermediate.
Chemical ID: MESH:D005947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases activityISORGD:101896480464CTDGlucose results in increased activity of ARNT protein

PMID:15767253
multiple interactionsISORGD:101896480464CTD[Glucose co-treated with Oxygen deficiency] inhibits the reaction [ARNT protein binds to HIF1A protein]

PMID:18227068
multiple interactionsISORGD:7327396480464CTDGlucose promotes the reaction [[ARNT protein binds to G6PC promoter] which results in increased expression of G6PC mRNA]

PMID:15767253
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.