GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | FASN | increases expression | EXP | | 6480464 | CTD | Glucose results in increased expression of FASN protein | PMID:18482975 PMID:23647015 | FASN | multiple interactions | EXP | | 6480464 | CTD | [Glucose results in increased expression of FASN protein] which results in increased abundance of Triglycerides; [INS protein co-treated with Glucose] results in increased expression of FASN mRNA; [Resveratrol results in increased activity of SIRT1 protein] inhibits the reaction [[Glucose results in increased expression of FASN protein] which results in increased abundance of Triglycerides]; Allopurinol inhibits the reaction [Glucose results in increased expression of FASN protein]; PRKAA2 protein promotes the reaction [SIRT1 protein inhibits the reaction [Glucose results in increased expression of FASN protein]]; Quercetin inhibits the reaction [Glucose results in increased expression of FASN protein]; SIRT1 protein inhibits the reaction [Glucose results in increased expression of FASN protein]; SRT1720 inhibits the reaction [[INS protein co-treated with Glucose] results in increased expression of FASN mRNA] | PMID:18482975 PMID:19724016 PMID:23647015 | FASN | increases expression | ISO | Fasn (Mus musculus) | 6480464 | CTD | Glucose results in increased expression of FASN mRNA | PMID:15066988 | FASN | increases expression | ISO | Fasn (Rattus norvegicus) | 6480464 | CTD | Glucose results in increased expression of FASN protein | PMID:23647015 | FASN | multiple interactions | ISO | Fasn (Rattus norvegicus) | 6480464 | CTD | Allopurinol inhibits the reaction [Glucose results in increased expression of FASN protein]; Glucose promotes the reaction [SREBF1 protein binds to FASN promoter]; Quercetin inhibits the reaction [Glucose results in increased expression of FASN protein] | PMID:22031849 PMID:23647015 | | ||||||||||||||||||||||
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