GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | FOXO3 | decreases expression | EXP | | 6480464 | CTD | Glucose results in decreased expression of FOXO3 protein | PMID:37417536 | FOXO3 | multiple interactions | EXP | | 6480464 | CTD | polyethylene glycol loxenatide inhibits the reaction [Glucose results in decreased expression of FOXO3 protein] | PMID:37417536 | FOXO3 | increases localization | ISO | Foxo3 (Mus musculus) | 6480464 | CTD | Glucose results in increased localization of FOXO3 protein | PMID:20370652 | FOXO3 | increases phosphorylation | ISO | Foxo3 (Mus musculus) | 6480464 | CTD | Glucose results in increased phosphorylation of FOXO3 protein | PMID:23090186 | FOXO3 | multiple interactions | ISO | Foxo3 (Rattus norvegicus) | 6480464 | CTD | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Glucose affects the localization of and results in increased phosphorylation of FOXO3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol inhibits the reaction [Glucose results in decreased phosphorylation of and affects the localization of FOXO3 protein]]; 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Glucose affects the localization of and results in increased phosphorylation of FOXO3 protein]; Acetylcysteine inhibits the reaction [Glucose results in decreased phosphorylation of FOXO3 protein]; Acetylcysteine inhibits the reaction [Glucose results in increased phosphorylation of FOXO3 protein]; Glucose results in decreased phosphorylation of and affects the localization of FOXO3 protein; Glucose results in increased phosphorylation of and affects the localization of FOXO3 protein; Resveratrol inhibits the reaction [Glucose results in decreased phosphorylation of and affects the localization of FOXO3 protein] | PMID:23159718 PMID:25471227 | FOXO3 | multiple interactions | ISO | Foxo3 (Mus musculus) | 6480464 | CTD | [[Resveratrol results in increased activity of SIRT1 protein] which results in increased phosphorylation of and results in decreased activity of FOXO3 protein] which results in decreased susceptibility to Glucose; AKT1 protein promotes the reaction [Glucose affects the phosphorylation of and affects the activity of FOXO3 protein]; FOXO3 protein promotes the reaction [Glucose results in increased cleavage of and results in increased activity of CASP1 protein]; FOXO3 protein promotes the reaction [Glucose results in increased cleavage of and results in increased activity of CASP3 protein]; Glucose affects the phosphorylation of and affects the activity of FOXO3 protein; Resveratrol inhibits the reaction [Glucose results in increased phosphorylation of FOXO3 protein] | PMID:20370652 PMID:23090186 | | ||||||||||||||||||||||
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