GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nlrp3 | increases response to substance | EXP | | 6480464 | CTD | NLRP3 protein results in increased susceptibility to Glucose | PMID:27783111 | Nlrp3 | multiple interactions | EXP | | 6480464 | CTD | NLRP3 protein promotes the reaction [Glucose results in decreased expression of TJP1 protein]; NLRP3 protein promotes the reaction [Glucose results in decreased expression of TJP2 protein]; NLRP3 protein promotes the reaction [Glucose results in increased secretion of HMGB1 protein] | PMID:27783111 | Nlrp3 | increases expression | ISO | Nlrp3 (Rattus norvegicus) | 6480464 | CTD | Glucose results in increased expression of NLRP3 protein | PMID:23647015 PMID:29031534 PMID:30031708 | Nlrp3 | increases expression | ISO | NLRP3 (Homo sapiens) | 6480464 | CTD | Glucose results in increased expression of NLRP3 mRNA; Glucose results in increased expression of NLRP3 protein | PMID:23647015 PMID:36066211 PMID:37473909 | Nlrp3 | multiple interactions | ISO | Nlrp3 (Rattus norvegicus) | 6480464 | CTD | [Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of NLRP3 protein; Allopurinol inhibits the reaction [Glucose results in increased expression of NLRP3 protein]; Artesunate inhibits the reaction [Glucose results in increased expression of NLRP3 protein]; diosmetin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of NLRP3 protein]; ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [Glucose results in increased expression of NLRP3 protein]; prolinedithiocarbamate inhibits the reaction [Glucose results in increased expression of NLRP3 protein]; Quercetin inhibits the reaction [Glucose results in increased expression of NLRP3 protein]; rhodioloside inhibits the reaction [Glucose results in increased expression of NLRP3 protein] | PMID:23647015 PMID:29031534 PMID:30031708 PMID:35191607 | Nlrp3 | multiple interactions | ISO | NLRP3 (Homo sapiens) | 6480464 | CTD | [Glucose co-treated with TGFB1 protein] results in increased expression of NLRP3 protein; [Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of NLRP3 protein; Allopurinol inhibits the reaction [Glucose results in increased expression of NLRP3 protein]; aucubin inhibits the reaction [[Glucose co-treated with TGFB1 protein] results in increased expression of NLRP3 protein]; bellidifolin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of NLRP3 protein]; Lipopolysaccharides inhibits the reaction [swietenine inhibits the reaction [Glucose results in increased expression of NLRP3 protein]]; Lipopolysaccharides promotes the reaction [Glucose results in increased expression of NLRP3 protein]; loganin inhibits the reaction [Glucose results in increased expression of NLRP3 mRNA]; loganin inhibits the reaction [Glucose results in increased expression of NLRP3 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [Glucose results in increased expression of NLRP3 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide promotes the reaction [swietenine inhibits the reaction [Glucose results in increased expression of NLRP3 protein]]; pyrrolidine dithiocarbamic acid inhibits the reaction [Glucose results in increased expression of NLRP3 protein]; pyrrolidine dithiocarbamic acid promotes the reaction [swietenine inhibits the reaction [Glucose results in increased expression of NLRP3 protein]]; Quercetin inhibits the reaction [Glucose results in increased expression of NLRP3 protein]; swietenine inhibits the reaction [Glucose results in increased expression of NLRP3 protein] | PMID:23647015 PMID:35961541 PMID:36066211 PMID:37127800 PMID:37473909 | | ||||||||||||||||||||||
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