GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ccl2 | increases expression | EXP | | 6480464 | CTD | Glucose results in increased expression of CCL2 mRNA; Glucose results in increased expression of CCL2 protein | PMID:17178593 PMID:17607302 PMID:36243327 | Ccl2 | increases secretion | EXP | | 6480464 | CTD | Glucose results in increased secretion of CCL2 protein | PMID:23329836 | Ccl2 | multiple interactions | EXP | | 6480464 | CTD | [lard co-treated with Cholesterol, Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose co-treated with Glyphosate] results in increased expression of CCL2 mRNA; [lard co-treated with Cholesterol, Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose] results in increased expression of CCL2 mRNA; manganese chloride inhibits the reaction [Glucose results in increased secretion of CCL2 protein]; MIR27B mRNA affects the reaction [Glucose results in increased expression of CCL2 protein]; SNHG1 affects the reaction [Glucose results in increased expression of CCL2 mRNA]; SNHG1 affects the reaction [Glucose results in increased expression of CCL2 protein]; SNHG1 affects the reaction [MIR27B mRNA affects the reaction [Glucose results in increased expression of CCL2 protein]] | PMID:23329836 PMID:36243327 PMID:37567420 | Ccl2 | increases expression | ISO | CCL2 (Homo sapiens) | 6480464 | CTD | Glucose results in increased expression of CCL2 mRNA; Glucose results in increased expression of CCL2 protein; Glucose results in increased expression of MCP1 mRNA | PMID:16143069 PMID:16600694 PMID:17655880 PMID:19132243 PMID:19225232 PMID:20542118 PMID:21367880 PMID:24436987 PMID:24513509 PMID:25338943 | Ccl2 | increases secretion | ISO | Ccl2 (Rattus norvegicus) | 6480464 | CTD | Glucose results in increased secretion of CCL2 protein | PMID:22036992 | Ccl2 | increases secretion | ISO | CCL2 (Homo sapiens) | 6480464 | CTD | Glucose results in increased secretion of CCL2 protein | PMID:16600694 PMID:17665966 PMID:23329836 | Ccl2 | multiple interactions | ISO | Ccl2 (Rattus norvegicus) | 6480464 | CTD | duanbanhuain A inhibits the reaction [Glucose results in increased secretion of CCL2 protein]; duanbanhuain B inhibits the reaction [Glucose results in increased secretion of CCL2 protein] | PMID:22036992 | Ccl2 | multiple interactions | ISO | CCL2 (Homo sapiens) | 6480464 | CTD | (R)-2-(3-((benzoxazol-2-yl-d4 (3-(4-methoxyphenoxy-d7)propyl)amino)methyl)phenoxy) butanoic acid inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CCL2 protein]; 2-(2,6-dimethyl-4-(3-(4-(methylthio)phenyl)-3-oxo-1-propenyl)phenoxyl)-2-methylpropanoic acid inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CCL2 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Glucose results in increased expression of CCL2 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Glucose results in increased expression of CCL2 protein]; [Glucose co-treated with fatostatin] results in increased expression of CCL2 mRNA; [osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of CCL2 mRNA; [osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CCL2 protein; [Resveratrol affects the localization of RELA protein] inhibits the reaction [Glucose results in increased expression of CCL2 mRNA]; [Resveratrol affects the localization of RELA protein] inhibits the reaction [Glucose results in increased expression of CCL2 protein]; [Valsartan co-treated with Simvastatin] inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of CCL2 mRNA]]; aspalathin inhibits the reaction [Glucose results in increased expression of CCL2 mRNA]; aspalathin inhibits the reaction [Glucose results in increased expression of CCL2 protein]; Aspirin inhibits the reaction [Glucose results in increased expression of CCL2 mRNA]; Aspirin inhibits the reaction [Glucose results in increased expression of CCL2 protein]; Aspirin inhibits the reaction [Glucose results in increased secretion of CCL2 protein]; Bezafibrate inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CCL2 protein]; CCL2 mRNA affects the reaction [Glucose results in increased expression of CCN2 protein]; chromic chloride inhibits the reaction [Glucose results in increased secretion of CCL2 protein]; chromium nicotinic acid complex inhibits the reaction [Glucose results in increased secretion of CCL2 protein]; Clofibrate inhibits the reaction [Glucose results in increased expression of CCL2 mRNA]; Clofibrate inhibits the reaction [Glucose results in increased expression of CCL2 protein]; Clofibrate inhibits the reaction [Glucose results in increased secretion of CCL2 protein]; diphenyleneiodonium inhibits the reaction [Glucose results in increased expression of CCL2 mRNA]; diphenyleneiodonium inhibits the reaction [Glucose results in increased secretion of CCL2 protein]; Fenofibrate inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CCL2 protein]; Fenofibrate inhibits the reaction [Glucose results in increased expression of CCL2 mRNA]; Fenofibrate inhibits the reaction [Glucose results in increased expression of CCL2 protein]; Fenofibrate inhibits the reaction [Glucose results in increased secretion of CCL2 protein]; Glucose inhibits the reaction [Fructose results in increased secretion of CCL2 protein]; Glucose promotes the reaction [AGT protein results in increased expression of CCL2 mRNA]; HTS 466284 inhibits the reaction [Glucose results in increased expression of CCL2 mRNA]; isoangustone A inhibits the reaction [Glucose results in increased expression of CCL2 mRNA]; lanifibranor inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CCL2 protein]; manganese chloride inhibits the reaction [Glucose results in increased secretion of CCL2 protein]; nothofagin inhibits the reaction [Glucose results in increased expression of CCL2 mRNA]; nothofagin inhibits the reaction [Glucose results in increased expression of CCL2 protein]; picolinic acid inhibits the reaction [Glucose results in increased secretion of CCL2 protein]; Pioglitazone inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CCL2 protein]; psicose inhibits the reaction [Glucose results in increased expression of CCL2 mRNA]; psicose inhibits the reaction [Glucose results in increased expression of CCL2 protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [Glucose results in increased expression of CCL2 mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Glucose results in increased secretion of CCL2 protein]; Quercetin inhibits the reaction [Glucose results in increased expression of MCP1 mRNA]; Resveratrol inhibits the reaction [Glucose results in increased expression of CCL2 mRNA]; Resveratrol inhibits the reaction [Glucose results in increased expression of CCL2 protein]; Rosiglitazone inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CCL2 protein]; saroglitazar inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CCL2 protein]; SB 203580 inhibits the reaction [Glucose results in increased expression of CCL2 mRNA]; SB 203580 inhibits the reaction [Glucose results in increased expression of CCL2 protein]; Selenium inhibits the reaction [Glucose results in increased expression of CCL2 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Glucose results in increased expression of CCL2 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Glucose results in increased secretion of CCL2 protein]; Valsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of CCL2 mRNA]] | PMID:16143069 PMID:16600694 PMID:17655880 PMID:17665966 PMID:19132243 PMID:19158351 PMID:19225232 PMID:20542118 PMID:21367880 PMID:23329836 PMID:24436987 PMID:24513509 PMID:25338943 PMID:29420703 PMID:32613381 | | ||||||||||||||||||||||
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