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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10649
Species: Mus musculus
RGD Object: Gene
Symbol: Gja1
Name: gap junction protein, alpha 1
Acc ID: CHEBI:17234
Term: glucose
Definition: An aldohexose used as a source of energy and metabolic intermediate.
Chemical ID: MESH:D005947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gja1increases expressionEXP 6480464CTDGlucose results in increased expression of GJA1 mRNAPMID:17178593
Gja1decreases expressionISOGJA1 (Homo sapiens)6480464CTDGlucose results in decreased expression of GJA1 proteinPMID:20578705
Gja1increases degradationISOGJA1 (Homo sapiens)6480464CTDGlucose results in increased degradation of GJA1 proteinPMID:20578705
Gja1increases expressionISOGja1 (Rattus norvegicus)6480464CTDGlucose results in increased expression of GJA1 proteinPMID:28713934
Gja1multiple interactionsISOGja1 (Rattus norvegicus)6480464CTDChloroquine inhibits the reaction [Resveratrol inhibits the reaction [Glucose results in increased expression of GJA1 protein]]; Chloroquine promotes the reaction [Glucose results in increased expression of GJA1 protein]; Resveratrol inhibits the reaction [Glucose results in increased expression of GJA1 protein]PMID:28713934
Gja1multiple interactionsISOGJA1 (Homo sapiens)6480464CTDresveratrol inhibits the reaction [Glucose results in increased degradation of GJA1 protein]PMID:20578705
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