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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:17230
Term: homocysteine
Definition: A sulfur-containing amino acid consisting of a glycine core with a 2-mercaptoethyl side-chain.
Chemical ID: MESH:D006710
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxincreases expressionEXP 6480464CTDHomocysteine results in increased expression of BAX mRNAPMID:31721048
Baxmultiple interactionsEXP 6480464CTDFolic Acid inhibits the reaction [Homocysteine results in increased expression of BAX mRNA]PMID:31721048
Baxaffects expressionISOBAX (Homo sapiens)6480464CTDHomocysteine affects the expression of BAX mRNA; Homocysteine affects the expression of BAX proteinPMID:29250709
Baxaffects localizationISOBAX (Homo sapiens)6480464CTDHomocysteine affects the localization of BAX proteinPMID:31885769
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDHomocysteine results in increased expression of BAX proteinPMID:16757814
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTDBAX protein inhibits the reaction [Cystathionine inhibits the reaction [Homocysteine results in increased activity of CASP3 protein]]; BTSA1 compound inhibits the reaction [Cystathionine inhibits the reaction [Homocysteine affects the localization of BAX protein]]; Cystathionine inhibits the reaction [Homocysteine affects the localization of BAX protein]; Cystathionine inhibits the reaction [Homocysteine results in increased expression of and affects the localization of BAX protein]; Folic Acid affects the reaction [Homocysteine affects the expression of BAX mRNA]; Folic Acid affects the reaction [Homocysteine affects the expression of BAX protein]; Homocysteine results in increased expression of and affects the localization of BAX protein; Zeranol inhibits the reaction [Homocysteine results in increased expression of BAX protein]PMID:16757814 PMID:29250709 PMID:31885769
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