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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620360
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfe2l2
Name: nuclear factor, erythroid 2-like 2
Acc ID: CHEBI:17226
Term: rosmarinic acid
Definition: The 1-carboxy-2-(2,4-dihydroxyphenyl)ethyl ester of trans-caffeic acid.
Chemical ID: MESH:C041376
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfe2l2increases expressionISORGD:7344316480464CTDrosmarinic acid results in increased expression of NFE2L2 mRNA, rosmarinic acid results in increased expression of NFE2L2 protein

PMID:31610155
Nfe2l2multiple interactionsISORGD:7344316480464CTD[lead acetate results in increased abundance of Lead] inhibits the reaction [rosmarinic acid results in increased expression of NFE2L2 protein], rosmarinic acid affects the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of NFE2L2 mRNA]

PMID:31610155
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.