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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2901
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il6
Name: interleukin 6
Acc ID: CHEBI:17226
Term: rosmarinic acid
Definition: The 1-carboxy-2-(2,4-dihydroxyphenyl)ethyl ester of trans-caffeic acid.
Chemical ID: MESH:C041376
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il6affects expressionEXP 6480464CTDrosmarinic acid affects the expression of IL6 protein

PMID:28744220
Il6decreases expressionEXP 6480464CTDrosmarinic acid results in decreased expression of IL6 protein

PMID:28789951
Il6multiple interactionsEXP 6480464CTD2-chloro-5-nitrobenzanilide inhibits the reaction [rosmarinic acid affects the expression of IL6 protein], T 0070907 inhibits the reaction [rosmarinic acid affects the expression of IL6 protein]

PMID:28744220
Il6decreases expressionISORGD:108026480464CTDrosmarinic acid results in decreased expression of IL6 mRNA

PMID:26804033
Il6increases expressionISORGD:108026480464CTDrosmarinic acid results in increased expression of IL6 mRNA

PMID:26804033
Il6multiple interactionsISORGD:108026480464CTDrosmarinic acid inhibits the reaction [Cadmium results in increased expression of IL6 protein]

PMID:23548128
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.