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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2891
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il1b
Name: interleukin 1 beta
Acc ID: CHEBI:17226
Term: rosmarinic acid
Definition: The 1-carboxy-2-(2,4-dihydroxyphenyl)ethyl ester of trans-caffeic acid.
Chemical ID: MESH:C041376
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il1bdecreases expressionEXP 6480464CTDrosmarinic acid results in decreased expression of IL1B mRNA, rosmarinic acid results in decreased expression of IL1B protein

PMID:25455894, PMID:28789951
Il1bmultiple interactionsISORGD:107906480464CTDrosmarinic acid inhibits the reaction [Cadmium results in increased expression of IL1B protein], rosmarinic acid inhibits the reaction [Particulate Matter results in increased expression of IL1B protein], rosmarinic acid inhibits the reaction [Vehicle Emissions results in increased expression of IL1B protein]

PMID:12684091, PMID:23548128
Il1bmultiple interactionsISORGD:7309816480464CTD[rosmarinic acid results in decreased expression of ADAM17 protein] inhibits the reaction [IL1B protein affects the localization of PROCR protein], [rosmarinic acid results in decreased expression of ADAM17 protein] inhibits the reaction [IL1B protein results in increased cleavage of and results in increased secretion of PROCR protein]

PMID:23774263
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.