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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2279
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cat
Name: catalase
Acc ID: CHEBI:17226
Term: rosmarinic acid
Definition: The 1-carboxy-2-(2,4-dihydroxyphenyl)ethyl ester of trans-caffeic acid.
Chemical ID: MESH:C041376
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Catincreases activityISORGD:7327406480464CTDrosmarinic acid results in increased activity of CAT protein

PMID:31610155
Catincreases expressionISORGD:7327406480464CTDrosmarinic acid results in increased expression of CAT mRNA

PMID:31610155
Catmultiple interactionsISORGD:7327406480464CTDrosmarinic acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased activity of CAT protein], rosmarinic acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of CAT mRNA]

PMID:31610155
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.