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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305991
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Procr
Name: protein C receptor
Acc ID: CHEBI:17226
Term: rosmarinic acid
Definition: The 1-carboxy-2-(2,4-dihydroxyphenyl)ethyl ester of trans-caffeic acid.
Chemical ID: MESH:C041376
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Procraffects localizationISORGD:13143506480464CTDrosmarinic acid affects the localization of PROCR protein

PMID:23774263
Procrmultiple interactionsISORGD:13143496480464CTD[rosmarinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ADAM17 protein]] which affects the localization of PROCR protein, [rosmarinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ADAM17 protein]] which results in decreased cleavage of and results in decreased secretion of PROCR protein, [rosmarinic acid results in decreased expression of ADAM17 protein] inhibits the reaction [IL1B protein affects the localization of PROCR protein], [rosmarinic acid results in decreased expression of ADAM17 protein] inhibits the reaction [IL1B protein results in increased cleavage of and results in increased secretion of PROCR protein], [rosmarinic acid results in decreased expression of ADAM17 protein] inhibits the reaction [TNF protein affects the localization of PROCR protein], [rosmarinic acid results in decreased expression of ADAM17 protein] inhibits the reaction [TNF protein results in increased cleavage of and results in increased secretion of PROCR protein], rosmarinic acid inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PROCR protein], rosmarinic acid results in decreased cleavage of and results in decreased secretion of PROCR protein

PMID:23774263
Procrmultiple interactionsISORGD:13143506480464CTDrosmarinic acid results in decreased cleavage of and results in decreased secretion of PROCR protein

PMID:23774263
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.