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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10473
Species: Mus musculus
RGD Object: Gene
Symbol: Nqo1
Name: NAD(P)H dehydrogenase, quinone 1
Acc ID: CHEBI:17183
Term: sanguinarine
Definition: A botanical anti-fungal agent that has formula C20H14NO4.
Chemical ID: MESH:C005705
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nqo1decreases expressionISONqo1 (Rattus norvegicus)6480464CTDsanguinarine results in decreased expression of NQO1 mRNA; sanguinarine results in decreased expression of NQO1 proteinPMID:24300172
Nqo1decreases expressionISONQO1 (Homo sapiens)6480464CTDsanguinarine results in decreased expression of NQO1 mRNA; sanguinarine results in decreased expression of NQO1 proteinPMID:22021338
Nqo1increases reductionISONqo1 (Rattus norvegicus)6480464CTDNQO1 protein results in increased reduction of sanguinarinePMID:24300172
Nqo1multiple interactionsISONqo1 (Rattus norvegicus)6480464CTDNQO1 protein inhibits the reaction [sanguinarine results in decreased expression of BCL2 mRNA]; NQO1 protein inhibits the reaction [sanguinarine results in decreased expression of BCL2 protein]; NQO1 protein inhibits the reaction [sanguinarine results in increased expression of BAX mRNA]; NQO1 protein inhibits the reaction [sanguinarine results in increased expression of BAX protein]PMID:24300172
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