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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1615200
Species: Mus musculus
RGD Object: Gene
Symbol: Fasn
Name: fatty acid synthase
Acc ID: CHEBI:171741
Term: cerulenin
Definition: An epoxydodecadienamide isolated from several species, including Acremonium, Acrocylindrum and Helicoceras. It inhibits the biosynthesis of several lipids by interfering with enzyme function.
Chemical ID: MESH:D002569
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fasndecreases activityEXP 6480464CTDCerulenin results in decreased activity of FASN proteinPMID:15707987
Fasndecreases expressionEXP 6480464CTDCerulenin results in decreased expression of FASN mRNAPMID:15707987
Fasndecreases activityISOFASN (Homo sapiens)6480464CTDCerulenin results in decreased activity of FASN proteinPMID:12798352
Fasnmultiple interactionsISOFASN (Homo sapiens)6480464CTD[Cerulenin results in decreased activity of FASN protein] which results in decreased abundance of PhosphorylcholinePMID:18723500
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