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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2901
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il6
Name: interleukin 6
Acc ID: CHEBI:17158
Term: methylglyoxal
Definition: A 2-oxo aldehyde derived from propanal.
Chemical ID: MESH:D011765
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il6increases expressionEXP 6480464CTDPyruvaldehyde results in increased expression of IL6 mRNAPMID:31103701
Il6affects expressionISOIL6 (Homo sapiens)6480464CTDPyruvaldehyde analog affects the expression of IL6 mRNAPMID:20200221
Il6increases expressionISOIl6 (Mus musculus)6480464CTDPyruvaldehyde results in increased expression of IL6 mRNA; Pyruvaldehyde results in increased expression of IL6 proteinPMID:25042521 PMID:26723916 PMID:29148590 PMID:34656697
Il6increases secretionISOIl6 (Mus musculus)6480464CTDPyruvaldehyde results in increased secretion of IL6 proteinPMID:28986142
Il6multiple interactionsISOIl6 (Mus musculus)6480464CTDacetovanillone inhibits the reaction [Pyruvaldehyde results in increased expression of IL6 protein]; bergenin inhibits the reaction [Pyruvaldehyde results in increased expression of IL6 protein]; honokiol affects the reaction [Pyruvaldehyde results in increased expression of IL6 protein]; Limonene inhibits the reaction [Pyruvaldehyde results in increased secretion of IL6 protein]; pimagedine inhibits the reaction [Pyruvaldehyde results in increased expression of IL6 protein]PMID:25042521 PMID:26723916 PMID:28986142 PMID:29148590
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