GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Il6 | increases expression | EXP | | 6480464 | CTD | Pyruvaldehyde results in increased expression of IL6 mRNA | PMID:31103701 | Il6 | affects expression | ISO | IL6 (Homo sapiens) | 6480464 | CTD | Pyruvaldehyde analog affects the expression of IL6 mRNA | PMID:20200221 | Il6 | increases expression | ISO | Il6 (Mus musculus) | 6480464 | CTD | Pyruvaldehyde results in increased expression of IL6 mRNA; Pyruvaldehyde results in increased expression of IL6 protein | PMID:25042521 PMID:26723916 PMID:29148590 PMID:34656697 | Il6 | increases secretion | ISO | Il6 (Mus musculus) | 6480464 | CTD | Pyruvaldehyde results in increased secretion of IL6 protein | PMID:28986142 | Il6 | multiple interactions | ISO | Il6 (Mus musculus) | 6480464 | CTD | acetovanillone inhibits the reaction [Pyruvaldehyde results in increased expression of IL6 protein]; bergenin inhibits the reaction [Pyruvaldehyde results in increased expression of IL6 protein]; honokiol affects the reaction [Pyruvaldehyde results in increased expression of IL6 protein]; Limonene inhibits the reaction [Pyruvaldehyde results in increased secretion of IL6 protein]; pimagedine inhibits the reaction [Pyruvaldehyde results in increased expression of IL6 protein] | PMID:25042521 PMID:26723916 PMID:28986142 PMID:29148590 | |
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