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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2806
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:17158
Term: methylglyoxal
Definition: A 2-oxo aldehyde derived from propanal.
Chemical ID: MESH:D011765
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionISORGD:7309016480464CTDPyruvaldehyde affects the expression of HMOX1 protein

PMID:22917016
decreases expressionISORGD:107176480464CTDPyruvaldehyde results in decreased expression of HMOX1 protein

PMID:28986142
multiple interactionsISORGD:107176480464CTDlimonene inhibits the reaction [Pyruvaldehyde results in decreased expression of HMOX1 protein]

PMID:28986142
multiple interactionsISORGD:7309016480464CTDAcetylcysteine affects the reaction [Pyruvaldehyde affects the expression of HMOX1 protein], NFE2L2 protein affects the reaction [resveratrol affects the reaction [Pyruvaldehyde affects the expression of HMOX1 protein]], resveratrol affects the reaction [Pyruvaldehyde affects the expression of HMOX1 protein], rosiglitazone affects the reaction [Pyruvaldehyde affects the expression of HMOX1 protein]

PMID:22917016
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.