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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2806
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:17158
Term: methylglyoxal
Definition: A 2-oxo aldehyde derived from propanal.
Chemical ID: MESH:D011765
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmox1affects expressionISOHMOX1 (Homo sapiens)6480464CTDPyruvaldehyde affects the expression of HMOX1 proteinPMID:22917016
Hmox1decreases expressionISOHmox1 (Mus musculus)6480464CTDPyruvaldehyde results in decreased expression of HMOX1 proteinPMID:28986142 PMID:29148590
Hmox1decreases expressionISOHMOX1 (Homo sapiens)6480464CTDPyruvaldehyde results in decreased expression of HMOX1 mRNA; Pyruvaldehyde results in decreased expression of HMOX1 proteinPMID:33930484
Hmox1multiple interactionsISOHmox1 (Mus musculus)6480464CTDbergenin inhibits the reaction [Pyruvaldehyde results in decreased expression of HMOX1 protein]; Limonene inhibits the reaction [Pyruvaldehyde results in decreased expression of HMOX1 protein]; pimagedine inhibits the reaction [Pyruvaldehyde results in decreased expression of HMOX1 protein]PMID:28986142 PMID:29148590
Hmox1multiple interactionsISOHMOX1 (Homo sapiens)6480464CTDAcetylcysteine affects the reaction [Pyruvaldehyde affects the expression of HMOX1 protein]; NFE2L2 protein affects the reaction [Resveratrol affects the reaction [Pyruvaldehyde affects the expression of HMOX1 protein]]; pimagedine inhibits the reaction [Pyruvaldehyde results in decreased expression of HMOX1 mRNA]; pimagedine inhibits the reaction [Pyruvaldehyde results in decreased expression of HMOX1 protein]; pterostilbene inhibits the reaction [Pyruvaldehyde results in decreased expression of HMOX1 mRNA]; pterostilbene inhibits the reaction [Pyruvaldehyde results in decreased expression of HMOX1 protein]; Resveratrol affects the reaction [Pyruvaldehyde affects the expression of HMOX1 protein]; Rosiglitazone affects the reaction [Pyruvaldehyde affects the expression of HMOX1 protein]PMID:22917016 PMID:33930484
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