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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69219
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Aldh2
Name: aldehyde dehydrogenase 2 family member
Acc ID: CHEBI:17153
Term: propanal
Definition: An aldehyde that consists of ethane bearing a formyl substituent. The parent of the class of propanals.
Chemical ID: MESH:C005556
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aldh2affects metabolic processingISOALDH2 (Homo sapiens)6480464CTDALDH2 protein polymorphism affects the metabolism of propionaldehydePMID:11744614
Aldh2increases metabolic processingISOALDH2 (Homo sapiens)6480464CTDALDH2 protein results in increased metabolism of propionaldehydePMID:20954713
Aldh2increases oxidationISOALDH2 (Homo sapiens)6480464CTDALDH2 protein results in increased oxidation of propionaldehydePMID:21349255 PMID:23295226
Aldh2multiple interactionsISOALDH2 (Homo sapiens)6480464CTDdaidzin inhibits the reaction [ALDH2 protein results in increased oxidation of propionaldehyde]; Magnesium promotes the reaction [ALDH2 protein results in increased oxidation of propionaldehyde]; molinate inhibits the reaction [ALDH2 protein results in increased metabolism of propionaldehyde]; molinate metabolite inhibits the reaction [ALDH2 protein results in increased metabolism of propionaldehyde]; molinate sulfoxide inhibits the reaction [ALDH2 protein results in increased metabolism of propionaldehyde]PMID:20954713 PMID:21349255 PMID:23295226
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