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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735440
Species: Homo sapiens
RGD Object: Gene
Symbol: NFKBIA
Name: NFKB inhibitor alpha
Acc ID: CHEBI:17026
Term: progesterone
Definition: A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
Chemical ID: MESH:D011374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NFKBIAincreases expressionEXP 6480464CTDProgesterone results in increased expression of NFKBIA mRNAPMID:18037150 PMID:21795739
NFKBIAmultiple interactionsEXP 6480464CTDProgesterone inhibits the reaction [IL1B protein results in increased degradation of NFKBIA protein]PMID:17437195
NFKBIAmultiple interactionsISONfkbia (Rattus norvegicus)6480464CTDProgesterone promotes the reaction [Hydrogen Peroxide results in increased degradation of NFKBIA protein]PMID:16284289
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