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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732293
Species: Mus musculus
RGD Object: Gene
Symbol: Chek1
Name: checkpoint kinase 1
Acc ID: CHEBI:17026
Term: progesterone
Definition: A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
Chemical ID: MESH:D011374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Chek1increases phosphorylationEXP 6480464CTDProgesterone results in increased phosphorylation of CHEK1 proteinPMID:22403396
Chek1multiple interactionsEXP 6480464CTDMifepristone inhibits the reaction [Progesterone results in increased phosphorylation of CHEK1 protein]PMID:22403396
Chek1decreases expressionISOChek1 (Rattus norvegicus)6480464CTDProgesterone results in decreased expression of CHEK1 mRNAPMID:20726854
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