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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70912
Species: Rattus norvegicus
RGD Object: Gene
Symbol: P2ry14
Name: purinergic receptor P2Y14
Acc ID: CHEBI:17026
Term: progesterone
Definition: A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
Chemical ID: MESH:D011374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:13472566480464CTDProgesterone results in increased expression of P2RY14 mRNA

PMID:17404688, PMID:20864642
multiple interactionsISORGD:13322766480464CTDProgesterone inhibits the reaction [Estradiol results in increased expression of P2RY14 mRNA]

PMID:18367319
multiple interactionsISORGD:13472566480464CTD[Estradiol co-treated with Progesterone] results in increased expression of P2RY14 mRNA

[Progesterone co-treated with Estradiol] results in increased expression of P2RY14 mRNA

PMID:17404688, PMID:20660070
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.