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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62366
Species: Mus musculus
RGD Object: Gene
Symbol: Inhba
Name: inhibin beta-A
Acc ID: CHEBI:17026
Term: progesterone
Definition: A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
Chemical ID: MESH:D011374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Inhbaincreases expressionEXP 6480464CTDProgesterone results in increased expression of INHBA mRNAPMID:22285243
Inhbadecreases expressionISOINHBA (Homo sapiens)6480464CTDProgesterone results in decreased expression of INHBA mRNAPMID:18070364 PMID:20660070
Inhbadecreases secretionISOINHBA (Homo sapiens)6480464CTDINHBA protein results in decreased secretion of ProgesteronePMID:20660033
Inhbaincreases expressionISOINHBA (Homo sapiens)6480464CTDProgesterone results in increased expression of INHBA mRNAPMID:17636213
Inhbamultiple interactionsISOInhba (Rattus norvegicus)6480464CTDINHBA protein inhibits the reaction [FSHB protein results in increased secretion of Progesterone]PMID:17954979
Inhbamultiple interactionsISOINHBA (Homo sapiens)6480464CTD4-(2-aminoethyl)benzenesulfonylfluoride inhibits the reaction [[Estradiol co-treated with Progesterone] results in decreased expression of INHBA mRNA]; [Estradiol co-treated with Progesterone] results in decreased expression of INHBA mRNA; [Progesterone co-treated with IL1B protein] results in increased expression of INHBA mRNA; [Progesterone co-treated with IL1B protein] results in increased secretion of [INHBA protein binds to INHBA protein]; FST protein inhibits the reaction [INHBA protein inhibits the reaction [Colforsin results in increased secretion of Progesterone]]; GDF9 protein inhibits the reaction [INHBA protein inhibits the reaction [FSHB protein results in increased secretion of Progesterone]]; GDF9 protein inhibits the reaction [INHBA protein results in decreased secretion of Progesterone]; IL11 protein promotes the reaction [INHBA protein promotes the reaction [[Estradiol co-treated with Progesterone] results in increased secretion of PRL protein]]; INHA mutant form inhibits the reaction [GDF9 protein inhibits the reaction [INHBA protein inhibits the reaction [FSHB protein results in increased secretion of Progesterone]]]; INHBA protein inhibits the reaction [Colforsin results in increased secretion of Progesterone]; INHBA protein inhibits the reaction [FSHB protein results in increased secretion of Progesterone]; INHBA protein promotes the reaction [[Estradiol co-treated with Progesterone] results in increased secretion of PRL protein]; INHBA protein promotes the reaction [IL11 protein promotes the reaction [[Estradiol co-treated with Progesterone] results in increased secretion of PRL protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [[Estradiol co-treated with Progesterone] results in decreased expression of INHBA mRNA]; pepstatin inhibits the reaction [[Estradiol co-treated with Progesterone] results in decreased expression of INHBA mRNA]; Progesterone results in increased secretion of [INHBA protein binds to INHBA protein]PMID:17636213 PMID:18936084 PMID:20074812 PMID:20660033 PMID:20660070
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