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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621176
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Scd
Name: stearoyl-CoA desaturase
Acc ID: CHEBI:17026
Term: progesterone
Definition: A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
Chemical ID: MESH:D011374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Scdaffects expressionISOScd1 (Mus musculus)6480464CTDProgesterone affects the expression of SCD1 mRNAPMID:17251523
Scdincreases expressionISOSCD (Homo sapiens)6480464CTDProgesterone results in increased expression of SCD mRNAPMID:18070364
Scdmultiple interactionsISOSCD (Homo sapiens)6480464CTD[Progesterone co-treated with Estradiol] inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in decreased expression of SCD1 mRNA]; [Progesterone co-treated with Estradiol] inhibits the reaction [Phenobarbital results in decreased expression of SCD1 mRNA]; Progesterone inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in decreased expression of SCD1 mRNA]; Progesterone inhibits the reaction [Phenobarbital results in decreased expression of SCD1 mRNA]PMID:21768169
Scdmultiple interactionsISOScd1 (Mus musculus)6480464CTD1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [[Progesterone co-treated with Estradiol] results in increased expression of SCD1 mRNA]; [Progesterone co-treated with Estradiol] results in increased expression of SCD1 mRNAPMID:21768169
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