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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620743
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bmp7
Name: bone morphogenetic protein 7
Acc ID: CHEBI:17026
Term: progesterone
Definition: A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
Chemical ID: MESH:D011374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bmp7increases expressionEXP 6480464CTDProgesterone results in increased expression of BMP7 mRNAPMID:20726854
Bmp7multiple interactionsEXP 6480464CTD[BMP7 protein results in decreased expression of STAR mRNA] inhibits the reaction [FSHB protein results in increased abundance of Progesterone]; GH1 protein inhibits the reaction [BMP7 protein inhibits the reaction [FSHB protein results in increased abundance of Progesterone]]; IGF1 protein inhibits the reaction [BMP7 protein inhibits the reaction [FSHB protein results in increased abundance of Progesterone]]PMID:22067323
Bmp7decreases expressionISOBMP7 (Homo sapiens)6480464CTDProgesterone results in decreased expression of BMP7 mRNAPMID:20085912
Bmp7multiple interactionsISOBMP7 (Homo sapiens)6480464CTD[Estradiol co-treated with Progesterone] results in decreased expression of BMP7 mRNA; BMP7 protein inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased expression of IGFBP1 mRNA]; BMP7 protein inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased secretion of IGFBP1 protein]PMID:20085912
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