Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   


RGD ID: 620021
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ihh
Name: Indian hedgehog signaling molecule
Acc ID: CHEBI:17026
Term: progesterone
Definition: A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
Chemical ID: MESH:D011374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionISORGD:15522376480464CTDProgesterone affects the expression of IHH

increases expressionISORGD:15522376480464CTDProgesterone results in increased expression of IHH, Progesterone results in increased expression of IHH mRNA

PMID:20232216, PMID:22238285
multiple interactionsISORGD:13503686480464CTD[Estradiol co-treated with Progesterone] results in decreased expression of IHH mRNA

multiple interactionsISORGD:15522376480464CTD[Estradiol co-treated with Progesterone] results in increased expression of IHH mRNA, ESR1 protein promotes the reaction [[Estradiol co-treated with Progesterone] results in increased expression of IHH mRNA]

PMID:22958837, PMID:25210133
Go Back to source page   Continue to Ontology report


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.