Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620021
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ihh
Name: Indian hedgehog signaling molecule
Acc ID: CHEBI:17026
Term: progesterone
Definition: A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
Chemical ID: MESH:D011374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionISORGD:15522376480464CTDProgesterone affects the expression of IHH

PMID:16794005
increases expressionISORGD:15522376480464CTDProgesterone results in increased expression of IHH, Progesterone results in increased expression of IHH mRNA

PMID:20232216, PMID:22238285
multiple interactionsISORGD:13503686480464CTD[Estradiol co-treated with Progesterone] results in decreased expression of IHH mRNA

PMID:20660070
multiple interactionsISORGD:15522376480464CTD[Estradiol co-treated with Progesterone] results in increased expression of IHH mRNA, ESR1 protein promotes the reaction [[Estradiol co-treated with Progesterone] results in increased expression of IHH mRNA]

PMID:22958837, PMID:25210133
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.