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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2253
Species: Rattus norvegicus
RGD Object: Gene
Symbol: S100g
Name: S100 calcium binding protein G
Acc ID: CHEBI:17026
Term: progesterone
Definition: A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
Chemical ID: MESH:D011374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionISORGD:13323556480464CTDProgesterone affects the expression of S100G mRNA

PMID:15509668
decreases expressionISORGD:13323556480464CTDProgesterone results in decreased expression of S100G mRNA

PMID:17556502, PMID:27264040
increases expressionISORGD:13323556480464CTDProgesterone results in increased expression of S100G mRNA

PMID:15509668, PMID:22238285
multiple interactionsISORGD:13323556480464CTDfulvestrant inhibits the reaction [Progesterone results in increased expression of S100G mRNA], Mifepristone inhibits the reaction [Progesterone results in decreased expression of S100G mRNA], NCOA2 protein affects the reaction [Progesterone results in decreased expression of S100G mRNA], S100G protein inhibits the reaction [Progesterone results in increased expression of BAX protein], S100G protein inhibits the reaction [Progesterone results in increased expression of CASP3 protein]

PMID:15509668, PMID:17556502, PMID:21882229, PMID:27264040
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.