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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2211
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bmp2
Name: bone morphogenetic protein 2
Acc ID: CHEBI:17026
Term: progesterone
Definition: A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
Chemical ID: MESH:D011374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTD[BMP2 protein results in decreased expression of STAR mRNA] inhibits the reaction [FSHB protein results in increased abundance of Progesterone], IGF1 protein inhibits the reaction [BMP2 protein inhibits the reaction [FSHB protein results in increased abundance of Progesterone]]

PMID:22067323
decreases abundanceISORGD:7331106480464CTDBMP2 protein results in decreased abundance of Progesterone

PMID:20639315, PMID:23313114
decreases expressionISORGD:7331106480464CTDProgesterone results in decreased expression of BMP2 mRNA

PMID:20660070
decreases expressionISORGD:7356026480464CTDProgesterone results in decreased expression of BMP2 mRNA

PMID:17556502
multiple interactionsISORGD:7331106480464CTD4-(2-aminoethyl)benzenesulfonylfluoride inhibits the reaction [[Estradiol co-treated with Progesterone] results in decreased expression of BMP2 mRNA], [Estradiol co-treated with Progesterone] results in decreased expression of BMP2 mRNA, N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [[Estradiol co-treated with Progesterone] results in decreased expression of BMP2 mRNA], NOG protein inhibits the reaction [BMP2 protein results in decreased abundance of Progesterone]

PMID:20639315, PMID:20660070
multiple interactionsISORGD:7356026480464CTDNCOA2 protein affects the reaction [Progesterone results in decreased expression of BMP2 mRNA], PGR protein affects the reaction [Progesterone results in decreased expression of BMP2 mRNA]

PMID:17556502
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.