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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1604061
Species: Homo sapiens
RGD Object: Gene
Symbol: CCL5
Name: C-C motif chemokine ligand 5
Acc ID: CHEBI:17026
Term: progesterone
Definition: A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
Chemical ID: MESH:D011374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CCL5increases expressionEXP 6480464CTDProgesterone results in increased expression of CCL5 mRNAPMID:21768398
CCL5multiple interactionsEXP 6480464CTD[Progesterone co-treated with Estradiol] results in decreased expression of CCL5 mRNA; TGFB1 protein promotes the reaction [Progesterone results in increased expression of CCL5 mRNA]PMID:17404688 PMID:21768398
CCL5multiple interactionsISOCcl5 (Rattus norvegicus)6480464CTD[Estradiol co-treated with Progesterone] results in decreased expression of CCL5 mRNA; [Estradiol co-treated with Progesterone] results in decreased expression of CCL5 proteinPMID:21277368
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