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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 14021273
Species: Sus scrofa
RGD Object: Gene
Symbol: GHRL
Name: ghrelin and obestatin prepropeptide
Acc ID: CHEBI:17026
Term: progesterone
Definition: A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
Chemical ID: MESH:D011374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GHRLdecreases secretionEXP 6480464CTDGHRL protein results in decreased secretion of ProgesteronePMID:19528263
GHRLincreases secretionEXP 6480464CTDGHRL protein results in increased secretion of ProgesteronePMID:17904772
GHRLmultiple interactionsEXP 6480464CTDAminoglutethimide promotes the reaction [GHRL protein results in decreased secretion of Progesterone]; GHRL protein results in decreased chemical synthesis of and results in decreased secretion of Progesterone; STAT1 protein inhibits the reaction [GHRL protein results in decreased secretion of Progesterone]PMID:19528263 PMID:22341706
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