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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1344914
Species: Homo sapiens
RGD Object: Gene
Symbol: S100G
Name: S100 calcium binding protein G
Acc ID: CHEBI:17026
Term: progesterone
Definition: A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
Chemical ID: MESH:D011374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
S100Gaffects expressionISOS100g (Mus musculus)6480464CTDProgesterone affects the expression of S100G mRNAPMID:15509668
S100Gdecreases expressionISOS100g (Mus musculus)6480464CTDProgesterone results in decreased expression of S100G mRNAPMID:17556502 PMID:27264040
S100Gincreases expressionISOS100g (Mus musculus)6480464CTDProgesterone results in increased expression of S100G mRNAPMID:15509668 PMID:22238285
S100Gmultiple interactionsISOS100g (Mus musculus)6480464CTDfulvestrant inhibits the reaction [Progesterone results in increased expression of S100G mRNA]; Mifepristone inhibits the reaction [Progesterone results in decreased expression of S100G mRNA]; NCOA2 protein affects the reaction [Progesterone results in decreased expression of S100G mRNA]; S100G protein inhibits the reaction [Progesterone results in increased expression of BAX protein]; S100G protein inhibits the reaction [Progesterone results in increased expression of CASP3 protein]PMID:15509668 PMID:17556502 PMID:21882229 PMID:27264040
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