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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10633
Species: Mus musculus
RGD Object: Gene
Symbol: Gfap
Name: glial fibrillary acidic protein
Acc ID: CHEBI:17026
Term: progesterone
Definition: A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
Chemical ID: MESH:D011374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gfapdecreases expressionEXP 6480464CTDProgesterone results in decreased expression of GFAP proteinPMID:23157231
Gfapmultiple interactionsEXP 6480464CTD[Estradiol co-treated with Progesterone] promotes the reaction [Cuprizone results in increased expression of GFAP mRNA]PMID:19031445
Gfapincreases expressionISOGfap (Rattus norvegicus)6480464CTDProgesterone results in increased expression of GFAP mRNAPMID:19360904 PMID:21770760
Gfapmultiple interactionsISOGfap (Rattus norvegicus)6480464CTDFinasteride inhibits the reaction [Progesterone results in increased expression of GFAP mRNA]PMID:19360904
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