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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10552
Species: Mus musculus
RGD Object: Gene
Symbol: Esr2
Name: estrogen receptor 2 (beta)
Acc ID: CHEBI:17026
Term: progesterone
Definition: A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
Chemical ID: MESH:D011374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDESR2 affects the reaction [[Estradiol co-treated with Progesterone] results in increased expression of OXT mRNA], Progesterone inhibits the reaction [ESR2 protein promotes the reaction [Estradiol results in increased expression of LPL mRNA]]

PMID:12834440, PMID:17974624
affects bindingISORGD:692136480464CTDProgesterone binds to ESR2 protein

PMID:19913605
decreases expressionISORGD:25826480464CTDProgesterone results in decreased expression of ESR2 mRNA

PMID:19094096
increases expressionISORGD:692136480464CTDProgesterone metabolite results in increased expression of ESR2 mRNA

PMID:17683929
multiple interactionsISORGD:25826480464CTD[Estradiol co-treated with Progesterone] results in decreased expression of ESR2 mRNA, Progesterone inhibits the reaction [Estradiol results in increased expression of ESR2 mRNA]

PMID:19094096, PMID:21277368
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.