RGD Gene Chemical Interaction Report

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	10552
Species:	Mus musculus
RGD Object:	Gene
Symbol:	Esr2
Name:	estrogen receptor 2 (beta)

Acc ID:	CHEBI:17026
Term:	progesterone
Definition:	A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
Chemical ID:	MESH:D011374

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	ESR2 affects the reaction [[Estradiol co-treated with Progesterone] results in increased expression of OXT mRNA], Progesterone inhibits the reaction [ESR2 protein promotes the reaction [Estradiol results in increased expression of LPL mRNA]]	PMID:12834440, PMID:17974624
affects binding	ISO	RGD:69213	6480464	CTD	Progesterone binds to ESR2 protein	PMID:19913605
decreases expression	ISO	RGD:2582	6480464	CTD	Progesterone results in decreased expression of ESR2 mRNA	PMID:19094096
increases expression	ISO	RGD:69213	6480464	CTD	Progesterone metabolite results in increased expression of ESR2 mRNA	PMID:17683929
multiple interactions	ISO	RGD:2582	6480464	CTD	[Estradiol co-treated with Progesterone] results in decreased expression of ESR2 mRNA, Progesterone inhibits the reaction [Estradiol results in increased expression of ESR2 mRNA]	PMID:19094096, PMID:21277368

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.

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