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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736260
Species: Mus musculus
RGD Object: Gene
Symbol: Eif2ak3
Name: eukaryotic translation initiation factor 2 alpha kinase 3
Acc ID: CHEBI:16990
Term: bilirubin IXalpha
Definition: A member of the class of biladienes that is a linear tetrapyrrole with the dipyrrole units being of both exovinyl and endovinyl type. A product of heme degradation, it is produced in the reticuloendothelial system by the reduction of biliverdin and transported to the liver as a complex with serum albumin.
Chemical ID: MESH:D001663
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Eif2ak3multiple interactionsISOEIF2AK3 (Homo sapiens)6480464CTDBilirubin results in increased phosphorylation of and results in increased activity of EIF2AK3 protein; EIF2AK3 mRNA promotes the reaction [Bilirubin results in increased expression of CXCL8 mRNA]PMID:20196124 PMID:27578021
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