GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | decreases activity | ISO | RGD:1350018 | 6480464 | CTD | Bilirubin results in decreased activity of UGT1A1 protein | PMID:15334623 | decreases glucuronidation | ISO | RGD:1350018 | 6480464 | CTD | UGT1A1 gene mutant form results in decreased glucuronidation of Bilirubin | PMID:17898154 | increases expression | ISO | RGD:1350018 | 6480464 | CTD | Bilirubin results in increased expression of UGT1A1 mRNA | PMID:15382119 | increases glucuronidation | ISO | RGD:1350018 | 6480464 | CTD | UGT1A1 protein results in increased glucuronidation of Bilirubin, UGT1A1 results in increased glucuronidation of Bilirubin | PMID:15988124, PMID:17599282, PMID:17898154, PMID:25370011 | increases glucuronidation | ISO | RGD:3935 | 6480464 | CTD | UGT1A1 protein results in increased glucuronidation of Bilirubin | PMID:12153725, PMID:15921999, PMID:17599282 | increases metabolic processing | ISO | RGD:1350018 | 6480464 | CTD | UGT1A1 protein results in increased metabolism of Bilirubin | PMID:23401472, PMID:27060662 | multiple interactions | ISO | RGD:1350018 | 6480464 | CTD | 5-methoxypsoralen promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin], chrysin promotes the reaction [UGT1A1 protein affects the glucuronidation of Bilirubin], chrysin promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin], Coumarins analog promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin], IL1B protein inhibits the reaction [Bilirubin results in increased expression of UGT1A1 mRNA], imperatorin promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin], UGT1A1 protein results in increased glucuronidation of and results in decreased activity of Bilirubin | PMID:10950852, PMID:15382119, PMID:15557560, PMID:17599282 | multiple interactions | ISO | RGD:3935 | 6480464 | CTD | 5-methoxypsoralen promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin], chrysin promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin], Coumarins analog promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin], imperatorin promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin] | PMID:17599282 | | ||||||||||||||||||||||
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