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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11476
Species: Mus musculus
RGD Object: Gene
Symbol: Ugt1a1
Name: UDP glucuronosyltransferase 1 family, polypeptide A1
Acc ID: CHEBI:16990
Term: bilirubin IXalpha
Definition: A member of the class of biladienes that is a linear tetrapyrrole with the dipyrrole units being of both exovinyl and endovinyl type. A product of heme degradation, it is produced in the reticuloendothelial system by the reduction of biliverdin and transported to the liver as a complex with serum albumin.
Chemical ID: MESH:D001663
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases activityISORGD:13500186480464CTDBilirubin results in decreased activity of UGT1A1 protein

PMID:15334623
decreases glucuronidationISORGD:13500186480464CTDUGT1A1 gene mutant form results in decreased glucuronidation of Bilirubin

PMID:17898154
increases expressionISORGD:13500186480464CTDBilirubin results in increased expression of UGT1A1 mRNA

PMID:15382119
increases glucuronidationISORGD:13500186480464CTDUGT1A1 protein results in increased glucuronidation of Bilirubin, UGT1A1 results in increased glucuronidation of Bilirubin

PMID:15988124, PMID:17599282, PMID:17898154, PMID:25370011
increases glucuronidationISORGD:39356480464CTDUGT1A1 protein results in increased glucuronidation of Bilirubin

PMID:12153725, PMID:15921999, PMID:17599282
increases metabolic processingISORGD:13500186480464CTDUGT1A1 protein results in increased metabolism of Bilirubin

PMID:23401472, PMID:27060662
multiple interactionsISORGD:13500186480464CTD5-methoxypsoralen promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin], chrysin promotes the reaction [UGT1A1 protein affects the glucuronidation of Bilirubin], chrysin promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin], Coumarins analog promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin], IL1B protein inhibits the reaction [Bilirubin results in increased expression of UGT1A1 mRNA], imperatorin promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin], UGT1A1 protein results in increased glucuronidation of and results in decreased activity of Bilirubin

PMID:10950852, PMID:15382119, PMID:15557560, PMID:17599282
multiple interactionsISORGD:39356480464CTD5-methoxypsoralen promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin], chrysin promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin], Coumarins analog promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin], imperatorin promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]

PMID:17599282
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.