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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1617608
Species: Mus musculus
RGD Object: Gene
Symbol: Cxcl15
Name: C-X-C motif chemokine ligand 15
Acc ID: CHEBI:16980
Term: geranial
Definition: A monoterpenoid that is (2E,6E)-octa-2,6-dienal substituted by methyl groups at positions 3 and 7.
Chemical ID: MESH:C007076
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cxcl15increases expressionISOCXCL8 (Homo sapiens)6480464CTDcitral results in increased expression of CXCL8 mRNA; citral results in increased expression of CXCL8 proteinPMID:21920952 PMID:25617811 PMID:29594315 PMID:31734321
Cxcl15increases secretionISOCXCL8 (Homo sapiens)6480464CTDcitral results in increased secretion of CXCL8 proteinPMID:20541004
Cxcl15multiple interactionsISOCXCL8 (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [citral results in increased expression of CXCL8 mRNA]PMID:21920952
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