Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3112
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcc1
Name: ATP binding cassette subfamily C member 1
Acc ID: CHEBI:16978
Term: leukotriene C4
Definition: A leukotriene that is (5S,7E,9E,11Z,14Z)-5-hydroxyicosa-7,9,11,14-tetraenoic acid in which a glutathionyl group is attached at position 6 via a sulfide linkage.
Chemical ID: MESH:D017997
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcc1affects bindingISOABCC1 (Homo sapiens)6480464CTDLeukotriene C4 analog binds to ABCC1 proteinPMID:15628876
Abcc1affects transportISOABCC1 (Homo sapiens)6480464CTDABCC1 protein affects the transport of Leukotriene C4PMID:11278867
Abcc1decreases transportISOABCC1 (Homo sapiens)6480464CTDABCC1 protein mutant form results in decreased transport of Leukotriene C4PMID:18336795
Abcc1increases uptakeISOABCC1 (Homo sapiens)6480464CTDABCC1 protein results in increased uptake of Leukotriene C4PMID:11306701
Abcc1multiple interactionsISOABCC1 (Homo sapiens)6480464CTD[Nimustine results in increased expression of ABCC1 protein] which results in increased transport of Leukotriene C4; Adenosine Triphosphate promotes the reaction [ABCC1 protein affects the transport of Leukotriene C4]; Apigenin inhibits the reaction [ABCC1 protein results in increased uptake of Leukotriene C4]; Bilirubin inhibits the reaction [ABCC1 protein affects the transport of Leukotriene C4]; estradiol-17 beta-glucuronide inhibits the reaction [ABCC1 protein affects the transport of Leukotriene C4]; Genistein affects the reaction [ABCC1 protein results in increased uptake of Leukotriene C4]; Glutathione Disulfide promotes the reaction [Leukotriene C4 analog binds to ABCC1 protein]; Glutathione promotes the reaction [Apigenin inhibits the reaction [ABCC1 protein results in increased uptake of Leukotriene C4]]; Glutathione promotes the reaction [Genistein affects the reaction [ABCC1 protein results in increased uptake of Leukotriene C4]]; Glutathione promotes the reaction [naringenin affects the reaction [ABCC1 protein results in increased uptake of Leukotriene C4]]; kaempferol inhibits the reaction [ABCC1 protein results in increased uptake of Leukotriene C4]; myricetin inhibits the reaction [ABCC1 protein results in increased uptake of Leukotriene C4]; naringenin affects the reaction [ABCC1 protein results in increased uptake of Leukotriene C4]; Quercetin inhibits the reaction [ABCC1 protein results in increased uptake of Leukotriene C4]PMID:11278867 PMID:11306701 PMID:15245331 PMID:15355964 PMID:15459206 PMID:15628876 PMID:9393752
Go Back to source page   Continue to Ontology report