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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1311889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Trpm2
Name: transient receptor potential cation channel, subfamily M, member 2
Acc ID: CHEBI:16960
Term: ADP-D-ribose
Definition: A nucleotide-sugar having ADP as the nucleotide fragment and D-ribofuranos-5-yl as the sugar component.
Chemical ID: MESH:D000246
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Trpm2multiple interactionsEXP 6480464CTDAdenosine Diphosphate Ribose promotes the reaction [TRPM2 protein results in increased transport of Calcium] Clotrimazole inhibits the reaction [Adenosine Diphosphate Ribose promotes the reaction [TRPM2 protein results in increased transport of Calcium]] Flufenamic Acid inhibits the reaction [Adenosine Diphosphate Ribose promotes the reaction [TRPM2 protein results in increased transport of Calcium]]

PMID:21900507
Trpm2increases activityISORGD:13235826480464CTDAdenosine Diphosphate Ribose results in increased activity of TRPM2 protein

PMID:18204483 PMID:22750002
Trpm2multiple interactionsISORGD:13235826480464CTD2-aminoethoxydiphenyl borate inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein] 4-amylcinnamoylanthranilic acid inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein] Copper Sulfate inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein] ferrous chloride inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein] lead nitrate inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein] Mercuric Chloride inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein] Miconazole inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein] Selenium Oxides inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]

PMID:18204483 PMID:22750002
Trpm2multiple interactionsISORGD:15584776480464CTDTRPM2 protein promotes the reaction [Adenosine Diphosphate Ribose results in increased uptake of Calcium]

PMID:20878536
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