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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731911
Species: Mus musculus
RGD Object: Gene
Symbol: Mmp9
Name: matrix metallopeptidase 9
Acc ID: CHEBI:16856
Term: glutathione
Definition: A tripeptide compound consisting of glutamic acid attached via its side chain to the N-terminus of cysteinylglycine.
Chemical ID: MESH:D005978
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp9multiple interactionsEXP 6480464CTDGlutathione inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of MMP9 protein]PMID:21722719
Mmp9affects bindingISOMMP9 (Homo sapiens)6480464CTDGlutathione binds to MMP9 proteinPMID:17015178
Mmp9decreases secretionISOMMP9 (Homo sapiens)6480464CTDGlutathione results in decreased secretion of MMP9 proteinPMID:15147517
Mmp9multiple interactionsISOMMP9 (Homo sapiens)6480464CTDGlutathione inhibits the reaction [4-aminophenylmercuriacetate results in increased activity of MMP9 protein]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Glutathione binds to MMP9 protein]PMID:17015178 PMID:17640567
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