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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10828
Species: Mus musculus
RGD Object: Gene
Symbol: Jun
Name: jun proto-oncogene
Acc ID: CHEBI:16856
Term: glutathione
Definition: A tripeptide compound consisting of glutamic acid attached via its side chain to the N-terminus of cysteinylglycine.
Chemical ID: MESH:D005978
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Junincreases phosphorylationEXP 6480464CTDGlutathione deficiency results in increased phosphorylation of JUN proteinPMID:12774022
Junmultiple interactionsEXP 6480464CTDGlutathione affects the reaction [Sodium Selenite results in increased expression of JUN mRNA]; Glutathione inhibits the reaction [Asbestos, Crocidolite results in increased expression of JUN mRNA]; Glutathione inhibits the reaction [tert-Butylhydroperoxide results in increased expression of JUN mRNA]PMID:15105052 PMID:15520183 PMID:18449455
Junmultiple interactionsISOJUN (Homo sapiens)6480464CTDGlutathione inhibits the reaction [Camptothecin results in increased phosphorylation of JUN protein]PMID:30266318
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