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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619571
Species: Mus musculus
RGD Object: Gene
Symbol: Mapk3
Name: mitogen-activated protein kinase 3
Acc ID: CHEBI:16842
Term: formaldehyde
Definition: An aldehyde resulting from the formal oxidation of methanol.
Chemical ID: MESH:D005557
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk3affects phosphorylationISOMAPK3 (Homo sapiens)6480464CTDFormaldehyde affects the phosphorylation of MAPK3 proteinPMID:36534342
Mapk3increases phosphorylationISOMAPK3 (Homo sapiens)6480464CTDFormaldehyde results in increased phosphorylation of MAPK3 proteinPMID:22138297 PMID:23219522 PMID:30236600
Mapk3multiple interactionsISOMAPK3 (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Formaldehyde results in increased phosphorylation of MAPK3 protein]; AG 1879 inhibits the reaction [Formaldehyde results in increased phosphorylation of MAPK3 protein]; Formaldehyde results in increased phosphorylation of and results in increased activity of MAPK3 protein; Ruthenium Red inhibits the reaction [Formaldehyde results in increased phosphorylation of MAPK3 protein]; silmitasertib affects the reaction [Formaldehyde affects the phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Formaldehyde results in increased phosphorylation of MAPK3 protein]PMID:16352387 PMID:22138297 PMID:23219522 PMID:36534342
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