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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1617608
Species: Mus musculus
RGD Object: Gene
Symbol: Cxcl15
Name: C-X-C motif chemokine ligand 15
Acc ID: CHEBI:16842
Term: formaldehyde
Definition: An aldehyde resulting from the formal oxidation of methanol.
Chemical ID: MESH:D005557
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cxcl15multiple interactionsEXP 6480464CTD[Formaldehyde co-treated with Benzene co-treated with Toluene co-treated with Xylenes] results in increased expression of CXCL15 protein; Formaldehyde promotes the reaction [ovalbumin-alum results in increased secretion of CXCL15 protein]PMID:24733833 PMID:37105513
Cxcl15affects expressionISOCXCL8 (Homo sapiens)6480464CTDFormaldehyde affects the expression of CXCL8PMID:24960057
Cxcl15decreases expressionISOCXCL8 (Homo sapiens)6480464CTDFormaldehyde results in decreased expression of CXCL8 proteinPMID:21087659
Cxcl15increases expressionISOCXCL8 (Homo sapiens)6480464CTDFormaldehyde results in increased expression of CXCL8 mRNA; Formaldehyde results in increased expression of CXCL8 proteinPMID:21147603 PMID:22138297 PMID:23649840 PMID:25617811 PMID:27664576 PMID:29594315 PMID:29860525
Cxcl15increases secretionISOCXCL8 (Homo sapiens)6480464CTDFormaldehyde results in increased secretion of CXCL8 proteinPMID:29860525
Cxcl15multiple interactionsISOCXCL8 (Homo sapiens)6480464CTD[Acrolein co-treated with Formaldehyde co-treated with Ozone] results in increased expression of CXCL8 protein; [Formaldehyde co-treated with lipopolysaccharide, E. coli O26-B6] results in decreased expression of CXCL8 mRNA; Cystathionine inhibits the reaction [Formaldehyde results in increased expression of CXCL8 protein]; Cysteine inhibits the reaction [Formaldehyde results in increased expression of CXCL8 protein]; Formaldehyde inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL8 protein]; Formaldehyde promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CXCL8 protein]PMID:16860297 PMID:21087659 PMID:27664576 PMID:29594315 PMID:36416909
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