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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620945
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp8
Name: caspase 8
Acc ID: CHEBI:16827
Term: corticosterone
Definition: A 21-hydroxy steroid that consists of pregn-4-ene substituted by hydroxy groups at positions 11 and 21 and oxo groups at positions 3 and 20. Corticosterone is a 21-carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands.
Chemical ID: MESH:D003345
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp8increases cleavageEXP 6480464CTDCorticosterone results in increased cleavage of CASP8 proteinPMID:29625166
Casp8multiple interactionsEXP 6480464CTDEstradiol inhibits the reaction [Corticosterone results in increased cleavage of CASP8 protein]; Estradiol promotes the reaction [Testosterone inhibits the reaction [Corticosterone results in increased cleavage of CASP8 protein]]; Testosterone inhibits the reaction [Corticosterone results in increased cleavage of CASP8 protein]; Testosterone promotes the reaction [Estradiol inhibits the reaction [Corticosterone results in increased cleavage of CASP8 protein]]PMID:29625166
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