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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2965
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kdr
Name: kinase insert domain receptor
Acc ID: CHEBI:16827
Term: corticosterone
Definition: A 21-hydroxy steroid that consists of pregn-4-ene substituted by hydroxy groups at positions 11 and 21 and oxo groups at positions 3 and 20. Corticosterone is a 21-carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands.
Chemical ID: MESH:D003345
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kdrdecreases expressionISOKdr (Mus musculus)6480464CTDCorticosterone results in decreased expression of KDR proteinPMID:21647420
Kdrmultiple interactionsISOKdr (Mus musculus)6480464CTD1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Corticosterone results in decreased expression of KDR protein]; Calcium promotes the reaction [Corticosterone results in decreased expression of KDR protein]; Corticosterone inhibits the reaction [KDR protein binds to NR3C1 protein]; Mifepristone inhibits the reaction [Corticosterone results in decreased expression of KDR protein]; NR3C1 protein promotes the reaction [Corticosterone results in decreased expression of KDR protein]PMID:21647420
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