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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10766
Species: Mus musculus
RGD Object: Gene
Symbol: Igf1r
Name: insulin-like growth factor I receptor
Acc ID: CHEBI:16827
Term: corticosterone
Definition: A 21-hydroxy steroid that consists of pregn-4-ene substituted by hydroxy groups at positions 11 and 21 and oxo groups at positions 3 and 20. Corticosterone is a 21-carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands.
Chemical ID: MESH:D003345
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Igf1rdecreases expressionISOIgf1r (Rattus norvegicus)6480464CTDCorticosterone results in decreased expression of IGF1R mRNA; Corticosterone results in decreased expression of IGF1R proteinPMID:12807724 PMID:29966748
Igf1rmultiple interactionsISOIgf1r (Rattus norvegicus)6480464CTD[IGF2R protein co-treated with IGF1R protein] affects the reaction [IGF2 protein inhibits the reaction [Corticosterone results in decreased expression of SOD2 protein]]PMID:24667322
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