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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10187
Species: Mus musculus
RGD Object: Gene
Symbol: Ar
Name: androgen receptor
Acc ID: CHEBI:16827
Term: corticosterone
Definition: A 21-hydroxy steroid that consists of pregn-4-ene substituted by hydroxy groups at positions 11 and 21 and oxo groups at positions 3 and 20. Corticosterone is a 21-carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands.
Chemical ID: MESH:D003345
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Araffects bindingISOAr (Rattus norvegicus)6480464CTDCorticosterone binds to AR proteinPMID:14565775
Arincreases activityISOAR (Homo sapiens)6480464CTDCorticosterone results in increased activity of AR proteinPMID:21543282
Armultiple interactionsISOAR (Homo sapiens)6480464CTD[Testosterone co-treated with Estradiol co-treated with Corticosterone] promotes the reaction [AR protein binds to TRAF6 protein]; Corticosterone binds to and results in increased activity of AR protein mutant form; Corticosterone inhibits the reaction [Metribolone results in increased activity of AR protein]; Corticosterone inhibits the reaction [Stanozolol binds to and results in increased activity of AR protein]PMID:11956172 PMID:18324785 PMID:29162470 PMID:29625166
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